KPV
Anti-Inflammatory PeptideresearchAlso known as: Lys-Pro-Val, α-MSH(11-13), Alpha-MSH C-terminal tripeptide
A naturally occurring anti-inflammatory tripeptide derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH), studied for its potent anti-inflammatory effects in the gut, skin, and systemically.
Overview
KPV (Lys-Pro-Val) is a tripeptide representing the C-terminal amino acids 11-13 of alpha-melanocyte-stimulating hormone (α-MSH). Despite being just three amino acids, KPV retains the potent anti-inflammatory activity of the full α-MSH molecule while lacking the melanogenic (tanning) and hormonal effects associated with the complete hormone. KPV exerts its anti-inflammatory effects primarily through inhibition of nuclear factor kappa B (NF-κB), a master transcription factor that regulates the expression of numerous pro-inflammatory genes. Research has demonstrated KPV's efficacy in models of inflammatory bowel disease (IBD), colitis, skin inflammation, and wound healing. Its small size allows for oral bioavailability and topical penetration, making it versatile in its delivery options. KPV has gained significant popularity in the biohacking community particularly for gut inflammation, where it is often used alongside BPC-157 for comprehensive GI healing protocols.
Mechanism of Action
KPV acts through several anti-inflammatory pathways: (1) Directly inhibits NF-κB activation by preventing nuclear translocation of the p65 subunit, suppressing transcription of pro-inflammatory genes including TNF-α, IL-1β, IL-6, and IL-8; (2) Enters cells via peptide transporters (PepT1) and interacts intracellularly with inflammatory signaling cascades; (3) Reduces activation of MAP kinase pathways involved in inflammatory signaling; (4) Decreases expression of inflammatory mediators in intestinal epithelial cells and immune cells; (5) Promotes wound healing through anti-inflammatory microenvironment modulation; (6) Modulates T-cell responses, reducing Th1/Th17 pro-inflammatory polarization; (7) Unlike full-length α-MSH, does not activate melanocortin receptors MC1R-MC5R, avoiding melanogenic and hormonal effects.
Molecular Formula
C16H30N4O4
Molecular Weight
342.43 g/mol
Sequence
Lys-Pro-Val
Dosage Protocols
Dose Range
200mcg – 500mcg
Frequency
1-2 times daily
Route
oral
Cycle Length
4-12 weeks
Oral administration is particularly relevant for gut inflammation as KPV can act directly on intestinal epithelial cells via PepT1 transport. Take on an empty stomach. Often stacked with BPC-157 for comprehensive gut healing.
Source: Preclinical research and community protocols
🧮 Personalized Dosage Calculator
💰 Estimated Pricing
Typical Supply
5mg vial or oral capsules
Last Updated
2026-02
Alpha-MSH fragment, anti-inflammatory. Oral and injectable forms. Telehealth: $80-200/mo. Popular for gut inflammation.
⚠️ Prices are estimates based on publicly available data and may vary significantly by vendor, location, and prescription status. This is not medical or financial advice.
Side Effects
| Effect | Severity |
|---|---|
| Mild GI discomfort | mild |
| Injection site irritation | mild |
| Headache | mild |
| Fatigue | mild |
Pros & Cons
Potent anti-inflammatory activity through direct NF-κB inhibition without immunosuppressive side effects
Multiple routes of administration (oral, subcutaneous, topical) providing versatility
No melanogenic or hormonal effects despite being derived from α-MSH
Simple tripeptide structure with excellent tolerability and minimal side effects
Promising preclinical evidence for IBD and colitis, addressing conditions with limited treatment options
Synergistic with BPC-157 for gut healing protocols
No human clinical trials — all evidence is preclinical (cell culture and animal models)
Optimal dosing for humans is not established through clinical research
Not FDA-approved, with variable quality from research suppliers
Stability of the small tripeptide in oral formulations may be variable
Research Studies
🩸 Blood Work
No specific bloodwork requirements reported for this peptide. General health panels are always recommended before starting any peptide protocol.
Legal Status
Not FDA-approved. Available as a research chemical and in some supplement formulations. Not specifically scheduled. Due to its small size and natural origin, it occupies a grey area between supplement and research peptide.
💬 Community Experiences
Share Your ExperienceUsing oral capsules for IBD symptoms. Inflammation markers dropped significantly on my last labs. Less bloating, less urgency. This alpha-MSH fragment is remarkable for gut inflammation.
Reduced gut inflammation and improved digestion. Combining with BPC-157 for a comprehensive gut healing protocol. The anti-inflammatory effects are noticeable within weeks.
Using topically for skin inflammation and redness. Calms irritated skin well. Also taking orally for general anti-inflammatory benefits. Multi-purpose peptide.
⚠️ Individual experiences may vary. These are user-submitted reports for informational purposes only. Always consult a healthcare professional before starting any peptide protocol.
Readers Also Viewed
Semaglutide
99An FDA-approved GLP-1 receptor agonist used for type 2 diabetes and chronic weight management, producing significant weight loss of 15-17% body weight in clinical trials.
BPC-157
98A 15-amino acid synthetic peptide derived from human gastric juice that promotes healing of tendons, ligaments, muscles, gut lining, and other tissues through multiple regenerative pathways.
Tirzepatide
97A first-in-class dual GIP/GLP-1 receptor agonist that produces up to 22.5% body weight loss, approved for type 2 diabetes and obesity management.
CJC-1295 + Ipamorelin (Combo)
95The most popular growth hormone peptide combination, pairing a GHRH analog (CJC-1295) with a ghrelin mimetic (Ipamorelin) for synergistic GH release with minimal side effects.
Related Peptides
Semaglutide
An FDA-approved GLP-1 receptor agonist used for type 2 diabetes and chronic weight management, producing significant weight loss of 15-17% body weight in clinical trials.
BPC-157
A 15-amino acid synthetic peptide derived from human gastric juice that promotes healing of tendons, ligaments, muscles, gut lining, and other tissues through multiple regenerative pathways.
Tirzepatide
A first-in-class dual GIP/GLP-1 receptor agonist that produces up to 22.5% body weight loss, approved for type 2 diabetes and obesity management.
CJC-1295 + Ipamorelin (Combo)
The most popular growth hormone peptide combination, pairing a GHRH analog (CJC-1295) with a ghrelin mimetic (Ipamorelin) for synergistic GH release with minimal side effects.