Linaclotide (Linzess)
Gastrointestinal PeptideresearchAlso known as: Linaclotide
FDA-approved 14-amino acid peptide for IBS-C and chronic constipation. Activates guanylate cyclase-C receptors to increase fluid secretion and reduce visceral pain.
Overview
FDA-approved 14-amino acid peptide for IBS-C and chronic constipation. Activates guanylate cyclase-C receptors to increase fluid secretion and reduce visceral pain. This peptide represents an important class in the therapeutic peptide landscape and is included in Peptide Playbook for comprehensive education.
Mechanism of Action
See summary for primary mechanism. Detailed pharmacology available in referenced studies.
Molecular Formula
See literature
Molecular Weight
See literature
Sequence
See literature
Dosage Protocols
Dose Range
Varies – Varies
Frequency
Per protocol
Route
varies
Cycle Length
Per protocol
Dosing must be determined by a licensed healthcare provider based on individual assessment.
Source: Clinical literature
🧮 Personalized Dosage Calculator
💰 Estimated Pricing
Typical Supply
145/290mcg capsules, 30ct
Last Updated
2026-02
Brand name Linzess. Prescription required. Insurance often covers.
⚠️ Prices are estimates based on publicly available data and may vary significantly by vendor, location, and prescription status. This is not medical or financial advice.
Side Effects
| Effect | Severity |
|---|---|
| varies |
Pros & Cons
Research-backed therapeutic compound
Specific mechanism of action
Clinical data available
Part of growing peptide therapeutics field
May require prescription
Individual response varies
Not all uses FDA-approved
Requires medical supervision
Research Studies
🩸 Blood Work
No specific bloodwork requirements reported for this peptide. General health panels are always recommended before starting any peptide protocol.
Legal Status
Varies by jurisdiction. Consult local regulations and healthcare provider.
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