Palmitoyl Tetrapeptide-7
Cosmetic / Anti-Inflammatory PeptideapprovedAlso known as: Pal-GQPR, Rigin, Palmitoyl Tetrapeptide-3, Matrixyl 3000 component
A lipopeptide used in cosmetic skincare that reduces inflammation-driven skin aging by suppressing IL-6 and other inflammatory cytokines, often paired with Palmitoyl Tripeptide-1 in anti-wrinkle formulations.
Overview
Palmitoyl Tetrapeptide-7 is a synthetic lipopeptide consisting of four amino acids (Gly-Gln-Pro-Arg) conjugated to a palmitic acid chain for enhanced skin penetration. Originally known as Rigin, it was developed as an anti-inflammatory cosmetic peptide that targets immunosenescence-driven skin aging. As skin ages, chronic low-grade inflammation ('inflammaging') accelerates collagen breakdown and impairs repair. Palmitoyl Tetrapeptide-7 suppresses the secretion of interleukin-6 (IL-6) and other pro-inflammatory mediators, reducing this destructive inflammatory cascade. It is most commonly found in combination with Palmitoyl Tripeptide-1 in the trademarked complex Matrixyl 3000, one of the most popular anti-aging peptide combinations in clinical skincare. Together, they both reduce collagen destruction (via anti-inflammation) and stimulate new collagen production.
Mechanism of Action
Palmitoyl Tetrapeptide-7 works by suppressing the production of excess interleukin-6 (IL-6) by keratinocytes and other skin cells. IL-6 is a key driver of chronic inflammation in aging skin that upregulates matrix metalloproteinases (MMPs), enzymes that degrade collagen and elastin. By reducing IL-6 levels, the peptide slows the inflammatory destruction of the extracellular matrix. The palmitoyl (C16 fatty acid) lipid tail enhances penetration through the stratum corneum and improves cellular uptake. The tetrapeptide sequence mimics fragments of immunoglobulin G (IgG), which may explain its immunomodulatory properties.
Molecular Formula
C28H51N7O8
Molecular Weight
617.75 g/mol
Sequence
Pal-Gly-Gln-Pro-Arg
Dosage Protocols
Dose Range
0.001% – 0.01%
Frequency
Twice daily
Route
topical
Cycle Length
Ongoing
Typically found in serums and moisturizers in combination with Palmitoyl Tripeptide-1 (Matrixyl 3000). Apply to clean skin before heavier creams. Results visible after 4-8 weeks of consistent use.
Source: Cosmetic formulation guidelines
🧮 Personalized Dosage Calculator
💰 Estimated Pricing
Typical Supply
30mL serum
Last Updated
2026-02
Anti-aging skin peptide (Haloxyl component). Cosmetic serum pricing. Often combined with Palmitoyl Tripeptide-1 as Matrixyl 3000.
⚠️ Prices are estimates based on publicly available data and may vary significantly by vendor, location, and prescription status. This is not medical or financial advice.
Side Effects
| Effect | Severity |
|---|---|
| Skin irritation | mild |
| Redness | mild |
Pros & Cons
Targets the root cause of skin aging (chronic inflammation) rather than just symptoms
Excellent safety profile — used in cosmetics for over a decade with minimal adverse reports
Synergistic with Palmitoyl Tripeptide-1 — combined as Matrixyl 3000 for dual-action anti-aging
Non-invasive topical application with no injections required
Effects are subtle and cosmetic-grade — not comparable to injectable peptides or medical procedures
Limited peer-reviewed clinical data — most evidence is from manufacturer-sponsored studies
Concentration in commercial products is often very low and may not match study doses
Research Studies
🩸 Blood Work
No specific bloodwork requirements reported for this peptide. General health panels are always recommended before starting any peptide protocol.
Legal Status
Widely used in cosmetic formulations. Not a drug — regulated as a cosmetic ingredient. Available in numerous commercial skincare products. No prescription required.
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