Palmitoyl Tripeptide-1
Cosmetic LipopeptidecosmeticAlso known as: Pal-GHK, Palmitoyl Oligopeptide, Biopeptide-CL, Collagen Peptide
A lipopeptide that mimics the body's natural collagen-repair signal, stimulating collagen I, III, and IV synthesis and glycosaminoglycan production for anti-aging skin benefits.
Overview
Palmitoyl Tripeptide-1 is a synthetic lipopeptide consisting of the tripeptide sequence Gly-His-Lys (GHK) linked to a palmitoyl (palmitic acid) fatty acid chain. The GHK sequence is a naturally occurring fragment released during collagen breakdown that signals the body to produce new collagen — it essentially mimics a 'wound signal' that triggers repair processes. The palmitoyl group enhances skin penetration and stability. This peptide stimulates production of collagen types I, III, and IV, as well as fibronectin and glycosaminoglycans (including hyaluronic acid) in the dermis. It is often combined with Palmitoyl Tetrapeptide-7 in the commercial product Matrixyl 3000 for synergistic anti-aging effects. Palmitoyl Tripeptide-1 is one of the most clinically supported cosmetic peptides available.
Mechanism of Action
Palmitoyl Tripeptide-1 activates collagen repair pathways: (1) The GHK fragment mimics collagen breakdown products, signaling fibroblasts to increase collagen synthesis; (2) Activates TGF-beta signaling cascade in dermal fibroblasts; (3) Upregulates genes for collagen I, III, and IV production; (4) Stimulates glycosaminoglycan (GAG) synthesis including hyaluronic acid; (5) Promotes fibronectin production for extracellular matrix integrity; (6) The palmitoyl chain enables penetration through the stratum corneum lipid barrier; (7) Mild wound-healing signaling without actual tissue damage.
Molecular Formula
C26H47N5O5
Molecular Weight
509.68 g/mol
Sequence
Pal-Gly-His-Lys
Dosage Protocols
Dose Range
50 ppm – 500 ppm
Frequency
Twice daily
Route
topical
Cycle Length
Ongoing
Apply to cleansed skin, focusing on areas of concern (face, neck, décolletage). Often combined with Palmitoyl Tetrapeptide-7 (as Matrixyl 3000). Results typically visible after 8-12 weeks.
Source: Cosmeceutical formulation guidelines and clinical studies
🧮 Personalized Dosage Calculator
💰 Estimated Pricing
Typical Supply
30mL serum
Last Updated
2026-02
Collagen-stimulating skin peptide. Part of Matrixyl 3000. Widely available in anti-aging skincare products.
⚠️ Prices are estimates based on publicly available data and may vary significantly by vendor, location, and prescription status. This is not medical or financial advice.
Side Effects
| Effect | Severity |
|---|---|
| Mild irritation | mild |
| Breakouts | mild |
Pros & Cons
Mimics natural collagen repair signaling for biologically relevant anti-aging effects
Clinical studies showing measurable reduction in wrinkle depth and improvement in skin firmness
Excellent safety profile with decades of cosmetic use
Synergizes well with other cosmetic peptides, especially in Matrixyl 3000 formulations
Results are gradual and require months of consistent use
Topical application limits the amount reaching viable dermal cells
Less potent than injectable treatments (fillers, Botox) for visible aging
Research Studies
🩸 Blood Work
No specific bloodwork requirements reported for this peptide. General health panels are always recommended before starting any peptide protocol.
Legal Status
Commercially available as a cosmetic ingredient. No prescription required. Widely used in anti-aging skincare formulations globally. No regulatory restrictions.
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