Pinealon
Bioregulator PeptideresearchAlso known as: EDR Peptide, Glu-Asp-Arg
A short tripeptide bioregulator that targets the pineal gland, supporting melatonin production, sleep quality, and neuroprotection.
Overview
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by Russian scientist Vladimir Khavinson as part of the bioregulator peptide family. It specifically targets the pineal gland, the brain's melatonin-producing center. Research suggests Pinealon can help restore declining melatonin production associated with aging, improve sleep architecture, and provide neuroprotective effects. It is part of a broader class of Khavinson peptides that target specific organs and tissues.
Mechanism of Action
Pinealon acts as a gene regulator targeting pinealocytes (pineal gland cells): (1) Binds to DNA in pineal gland cells, modulating gene expression related to melatonin synthesis; (2) Restores age-related decline in melatonin production; (3) Provides antioxidant protection to pineal tissue; (4) May influence circadian rhythm regulation; (5) Shows neuroprotective effects by reducing oxidative stress in brain tissue.
Molecular Formula
C15H25N5O8
Molecular Weight
407.38 g/mol
Sequence
Glu-Asp-Arg
Dosage Protocols
Dose Range
10mg – 20mg
Frequency
Daily
Route
oral (sublingual or capsule)
Cycle Length
10-30 days, repeated periodically
Often taken as sublingual capsules. Cycle 10 days on, break, repeat.
Source: Khavinson research protocols
🧮 Personalized Dosage Calculator
💰 Estimated Pricing
Typical Supply
Sublingual capsules
Last Updated
2026-02
Available from specialty bioregulator suppliers.
⚠️ Prices are estimates based on publicly available data and may vary significantly by vendor, location, and prescription status. This is not medical or financial advice.
Side Effects
| Effect | Severity |
|---|---|
| mild | |
| mild |
Pros & Cons
Non-hormonal approach to improving melatonin production
Oral administration (no injections needed)
Short cycles with lasting effects
Good safety profile in research
Supports natural circadian rhythm
Limited Western clinical trials
Primarily researched in Russia
Effects may be subtle
Not FDA-approved
Mechanism not fully understood
Research Studies
🩸 Blood Work
No specific bloodwork requirements reported for this peptide. General health panels are always recommended before starting any peptide protocol.
Legal Status
Available as a research peptide and supplement in many countries. Not FDA-approved.
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